Cytochrome P-450 enzymes involved in genetic polymorphism of drug oxidation in humans.
نویسندگان
چکیده
The animals were subjected to hormone treatment for 1 week. Hormones were administered either continuously via osmotic minipumps (m.p.) or intermittently by subcutaneous injections once ( 1 x s.c.) or twice (2 x s.c.) daily. Daily doses were 120 pg for GH and 100 pg for methyltrienolone, respectively. Lane I , control female; lane 2, hypophysectomized (Hx) female; lane 3, female + androgen (methyltrienolone) 1 x s.c.; lane 4, control male; lane 5 , male + GH m.p.; lane 6, Hx male; lane 7, Hx male + GH m.p.; lane 8, Hx male + GH 2 x S.C.
منابع مشابه
Characterization of a human liver cytochrome P-450 involved in the oxidation of debrisoquine and other drugs by using antibodies raised to the analogous rat enzyme.
Debrisoquine 4-hydroxylase activity is a prototype for genetic polymorphism in oxidative drug metabolism in humans; approximately 10% of Caucasian populations exhibit the poor metabolizer phenotype, and the clearance of at least 14 other drugs has been shown to be deficient in patients exhibiting this phenotype. Antibodies prepared to a cytochrome P-450 shown to be responsible for debrisoquine ...
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عنوان ژورنال:
- Biochemical Society transactions
دوره 15 4 شماره
صفحات -
تاریخ انتشار 1987